Professor Fred Vom Saal, one of the researchers participating in the study. (Photo Credit: University of Missouri)

BPA found to adversely affect fish reproduction

UNITED STATES
Monday, March 30, 2015, 01:10 (GMT + 9)

Fish exposed to the endocrine-disrupting chemical bisphenol A (BPA) can pass adverse reproductive effects onto their offspring up to three generations later, shows a new study by the U.S. Geological Survey (USGS) and the University of Missouri (MU).

Often, aquatic environments such as rivers and streams become reservoirs for contaminants, including BPA - a chemical that is used in a variety of consumer products, such as water bottles, dental composites and resins used to line metal food and beverage containers.

“BPA has been proven to mimic the function of natural hormones in animals and humans. Fish and aquatic organisms often have the greatest exposure to such chemicals during critical periods in their development or even throughout entire life cycles,” said Ramji Bhandari, an assistant research professor of biological sciences at MU and a visiting scientist with the USGS. “This study shows that even though endocrine disruptors may not affect the life of the exposed fish, it may negatively affect future generations.”

Bhandari and fellow scientists Frederick vom Saal, Curators Professor of Biological Sciences in the College of Arts and Science at MU, and Don Tillitt, an adjunct professor of biological sciences and a research toxicologist with the USGS, exposed medaka (Oryzias latipes), or Japanese rice fish, to chemicals that included BPA for one week during embryonic development.

The team then studied their offspring through as many as four generations. Subsequent generations were never exposed to the chemicals. No apparent reproductive abnormalities appeared in the first two generations of fish; however, the researchers found that future generations showed a reduced rate of fertilization and increased embryo mortality.

“The shorter generations of the medaka fish make it an ideal candidate for this type of study,” Bhandari said.

Findings showed a 30 per cent decrease in the fertilization rate of fish two generations after exposure and a 20 per cent reduction after three generations. If those trends continued, the potential for declines in overall population numbers might be expected in generations far removed from the initial exposure.

“This study examined concentrations of BPA and other chemicals that are not expected to be found in most environmental situations,” Tillitt clarified. “However, concern remains about the possibility of passing on adverse reproductive effects to future generations at lower levels.”

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